TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Unterrainer, Josef M.
A1  - Petersen, Julia
A1  - Schmidt, Peter
A1  - Ernst, Mareike
A1  - Wirtz, Markus A.
A1  - Reinwarth, Anna C.
A1  - Wicke, Felix
A1  - Ghaemi Kerahrodi, Jasmin
A1  - Michal, Matthias
A1  - Münzel, Thomas
A1  - König, Jochem
A1  - Lackner, Karl J.
A1  - Pfeiffer, Norbert
A1  - Tüscher, Oliver
A1  - Galle, Peter R.
A1  - Beutel, Manfred
A1  - Wild, Philipp S.
T1  - Different risk and protective factors predict change of planning ability in middle versus older age
JF  - Scientific Reports
N2  - Abstract
                Age-related cognitive decline has become an increasingly relevant public health issue. However, risk and protective factors of cognitive decline have yet to be investigated prospectively taking into account genetic, lifestyle, physical and mental health factors. Population-based data from middle-aged (40 to 59 years; N  = 2,764) and older individuals (60 to 80 years; N  = 1,254) were drawn from a prospective community cohort study using the Tower of London (TOL) planning task. Assessments were repeated at a 5-year interval to investigate age-related changes in planning performance and to determine the impact of risk and protective factors. Planning performance improved in middle-aged, but declined in older participants over 5 years. SNPs affecting the dopamine system (COMT, DRD2) and APOE polymorphisms differentially predicted cognitive performance in older vs. middle-aged individuals. For older individuals, high alcohol consumption, antidepressant medication and living without a partner had additional negative predictive power on cognition. In contrast, undiagnosed hypertension, no obstructive lung disease, and fewer years of education predicted cognitive decline in the middle-aged group. The results inform screening for individuals particularly vulnerable to cognitive decline and interventions (e.g., focusing on lifestyle factors) to help maintain cognitive performance into old age.
KW  - -
KW  - Aging
KW  - Planning ability
KW  - Cognitive decline
KW  - Protective factors
KW  - Risk factors
KW  - Prospective cohort study
Y1  - 2024
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:frei129-opus4-34373
SN  - 2045-2322
SS  - 2045-2322
U6  - https://doi.org/10.1038/s41598-024-76784-1
DO  - https://doi.org/10.1038/s41598-024-76784-1
VL  - 14
IS  - 1
PB  - Nature Publishing Group UK
CY  - London
ER  -